3B6O

Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium)

3B6O の概要

• エントリーDOI: 10.2210/pdb3b6o/pdb
• 関連するPDBエントリー: 1Y97 2IOC 2O4G 2O4I 2OA8 3B6P
• 分子名称: Three prime repair exonuclease 1, LITHIUM ION, THYMIDINE-5'-PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: trex1, dedd, exonuclease, dnaq, lithium, catalysis, inhibition, deoxy-thimidine monophosphate (dtmp), dna damage, dna repair, hydrolase, magnesium, nucleus, phosphorylation
• 由来する生物種: Mus musculus (Mouse)
• 細胞内の位置: Nucleus (By similarity): Q91XB0
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 110008.64

構造登録者

Brucet, M.,Querol-Audi, J.,Fita, I.,Celada, A. (登録日: 2007-10-29, 公開日: 2008-09-23, 最終更新日: 2023-08-30)

• 主引用文献: Brucet, M.,Querol-Audi, J.,Bertlik, K.,Lloberas, J.,Fita, I.,Celada, A.; Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.; Protein Sci., 17:2059-2069, 2008; PubMed: 18780819; DOI: 10.1110/ps.036426.108

実験手法

X-RAY DIFFRACTION (2.1 Å)