3B6F

Nucleosome core particle treated with cisplatin

3B6F の概要

• エントリーDOI: 10.2210/pdb3b6f/pdb
• 関連するPDBエントリー: 1KX5 3B6G
• 分子名称: 147-MER DNA, Histone H3.2, Histone H4, ... (7 entities in total)
• 機能のキーワード: nucleosome, chromatin, platinum adduct, cisplatin, anti-cancer, drug, acetylation, chromosomal protein, dna-binding, methylation, nucleosome core, nucleus, phosphorylation, ubl conjugation, structural protein-dna complex, structural protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P84233 P62799 P02281; Nucleus (By similarity): Q6AZJ8
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 199426.87

構造登録者

Wu, B.,Davey, C.A. (登録日: 2007-10-29, 公開日: 2007-12-25, 最終更新日: 2023-11-01)

主引用文献

Wu, B.,Droge, P.,Davey, C.A.
Site selectivity of platinum anticancer therapeutics
Nat.Chem.Biol., 4:110-112, 2008

PubMed Abstract: X-ray crystallographic and biochemical investigation of the reaction of cisplatin and oxaliplatin with nucleosome core particle and naked DNA reveals that histone octamer association can modulate DNA platination. Adduct formation also occurs at specific histone methionine residues, which could serve as a nuclear platinum reservoir influencing adduct transfer to DNA. Our findings suggest that the nucleosome center may provide a favorable target for the design of improved platinum anticancer drugs.

PubMed: 18157123
DOI: 10.1038/nchembio.2007.58

実験手法

X-RAY DIFFRACTION (3.45 Å)