3B68

Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-4

3B68 の概要

• エントリーDOI: 10.2210/pdb3b68/pdb
• 関連するPDBエントリー: 2AXA 3B5R 3B65 3B66 3B67
• 分子名称: Androgen receptor, (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide (3 entities in total)
• 機能のキーワード: androgen receptor, sarm, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, polymorphism, steroid-binding, transcription, transcription regulation, triplet repeat expansion, ubl conjugation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P10275
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29487.43

構造登録者

Bohl, C.E.,Miller, D.D.,Dalton, J.T. (登録日: 2007-10-27, 公開日: 2008-09-09, 最終更新日: 2023-08-30)

• 主引用文献: Bohl, C.E.,Wu, Z.,Chen, J.,Mohler, M.L.,Yang, J.,Hwang, D.J.,Mustafa, S.,Miller, D.D.,Bell, C.E.,Dalton, J.T.; Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators; Bioorg.Med.Chem.Lett., 18:5567-5570, 2008; PubMed: 18805694; DOI: 10.1016/j.bmcl.2008.09.002

実験手法

X-RAY DIFFRACTION (1.9 Å)