3B5R
Crystal structure of the androgen receptor ligand binding domain in complex with SARM C-31
Summary for 3B5R
Entry DOI | 10.2210/pdb3b5r/pdb |
Related | 2axa 3B65 3B66 3B67 3B68 |
Descriptor | Androgen receptor, (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide (3 entities in total) |
Functional Keywords | androgen receptor, nonsteroidal, sarm, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, polymorphism, steroid-binding, transcription, transcription regulation, triplet repeat expansion, ubl conjugation, zinc, zinc-finger |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P10275 |
Total number of polymer chains | 1 |
Total formula weight | 29462.83 |
Authors | Bohl, C.E.,Miller, D.D.,Dalton, J.T. (deposition date: 2007-10-26, release date: 2008-09-09, Last modification date: 2024-02-21) |
Primary citation | Bohl, C.E.,Wu, Z.,Chen, J.,Mohler, M.L.,Yang, J.,Hwang, D.J.,Mustafa, S.,Miller, D.D.,Bell, C.E.,Dalton, J.T. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Bioorg.Med.Chem.Lett., 18:5567-5570, 2008 Cited by PubMed: 18805694DOI: 10.1016/j.bmcl.2008.09.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report