3B5B
Crystal structure of the thymidylate synthase k48q
Summary for 3B5B
Entry DOI | 10.2210/pdb3b5b/pdb |
Descriptor | Thymidylate synthase, 2'-DEOXY-5-NITROURIDINE 5'-MONOPHOSPHATE, FORMIC ACID, ... (5 entities in total) |
Functional Keywords | thymidylate synthase, 5-no2-dump, substrate anologue, methyltransferase, nucleotide biosynthesis, repressor, rna-binding, transferase, translation regulation |
Biological source | Escherichia coli BL21 |
Total number of polymer chains | 2 |
Total formula weight | 61829.63 |
Authors | Sotelo-Mundo, R.R.,Arreola, R.,Maley, F.,Montfort, W.R. (deposition date: 2007-10-25, release date: 2007-12-25, Last modification date: 2023-08-30) |
Primary citation | Arvizu-Flores, A.A.,Sugich-Miranda, R.,Arreola, R.,Garcia-Orozco, K.D.,Velazquez-Contreras, E.F.,Montfort, W.R.,Maley, F.,Sotelo-Mundo, R.R. Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: Calorimetric and crystallographic analysis of the K48Q mutant. Int.J.Biochem.Cell Biol., 40:2206-2217, 2008 Cited by PubMed: 18403248DOI: 10.1016/j.biocel.2008.02.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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