3B3K

Crystal structure of the complex between PPARgamma and the full agonist LT175

3B3K の概要

• エントリーDOI: 10.2210/pdb3b3k/pdb
• 関連するPDBエントリー: 1FM9 1K74 1PRG
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (3 entities in total)
• 機能のキーワード: bundle of alpha-helices, small four-strnded beta-sheet, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphorylation, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65379.67

構造登録者

Pochetti, G.,Montanari, R.,Mazza, F.,Loiodice, F.,Fracchiolla, G.,Crestani, M.,Godio, C. (登録日: 2007-10-22, 公開日: 2008-10-28, 最終更新日: 2023-11-01)

• 主引用文献: Montanari, R.,Saccoccia, F.,Scotti, E.,Crestani, M.,Godio, C.,Gilardi, F.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Tortorella, P.,Lavecchia, A.,Novellino, E.,Mazza, F.,Aschi, M.,Pochetti, G.; Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design; J.Med.Chem., 51:7768-7776, 2008; PubMed: 19053776; DOI: 10.1021/jm800733h

実験手法

X-RAY DIFFRACTION (2.6 Å)