3B2Z

Crystal Structure of ADAMTS4 (apo form)

3B2Z の概要

• エントリーDOI: 10.2210/pdb3b2z/pdb
• 分子名称: ADAMTS-4, ZINC ION, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: metalloprotease, aggrecanase, cleavage on pair of basic residues, extracellular matrix, glycoprotein, hydrolase, metal-binding, secreted, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (By similarity): O75173
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 274937.80

構造登録者

Mosyak, L.,Stahl, M.,Somers, W. (登録日: 2007-10-19, 公開日: 2007-12-25, 最終更新日: 2023-08-30)

• 主引用文献: Mosyak, L.,Georgiadis, K.,Shane, T.,Svenson, K.,Hebert, T.,McDonagh, T.,Mackie, S.,Olland, S.,Lin, L.,Zhong, X.,Kriz, R.,Reifenberg, E.L.,Collins-Racie, L.A.,Corcoran, C.,Freeman, B.,Zollner, R.,Marvell, T.,Vera, M.,Sum, P.E.,Lavallie, E.R.,Stahl, M.,Somers, W.; Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.; Protein Sci., 17:16-21, 2008; PubMed: 18042673; DOI: 10.1110/ps.073287008

実験手法

X-RAY DIFFRACTION (2.8 Å)