3B2U

Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8

3B2U の概要

• エントリーDOI: 10.2210/pdb3b2u/pdb
• 関連するPDBエントリー: 3B2V
• 分子名称: IMC-11F8 Fab Light chain, IMC-11F8 Fab Heavy chain, Epidermal growth factor receptor, ... (10 entities in total)
• 機能のキーワード: cell surface receptor; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug, anti-oncogene, atp-binding, cell cycle, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, secreted, transferase, transmembrane, tyrosine-protein kinase, immune system-transferase complex, immune system/transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 577651.09

構造登録者

Ferguson, K.M.,Li, S.,Kussie, P. (登録日: 2007-10-19, 公開日: 2008-02-19, 最終更新日: 2023-08-30)

• 主引用文献: Li, S.,Kussie, P.,Ferguson, K.M.; Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.; Structure, 16:216-227, 2008; PubMed: 18275813; DOI: 10.1016/j.str.2007.11.009

実験手法

X-RAY DIFFRACTION (2.58 Å)