3AY4
Crystal structure of nonfucosylated Fc complexed with bis-glycosylated soluble form of Fc gamma receptor IIIa
Summary for 3AY4
Entry DOI | 10.2210/pdb3ay4/pdb |
Related | 1E4K 1T83 1T89 2DTS 3AVE |
Descriptor | Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | immune system, complex, fc fragment, igg, receptor, cd16, gamma |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 75844.47 |
Authors | Mizushima, T.,Takemoto, E.,Yagi, H.,Shibata-Koyama, M.,Isoda, Y.,Iida, S.,Satoh, M.,Kato, K. (deposition date: 2011-04-28, release date: 2011-08-03, Last modification date: 2023-11-01) |
Primary citation | Mizushima, T.,Yagi, H.,Takemoto, E.,Shibata-Koyama, M.,Isoda, Y.,Iida, S.,Masuda, K.,Satoh, M.,Kato, K. Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans Genes Cells, 16:1071-1080, 2011 Cited by PubMed: 22023369DOI: 10.1111/j.1365-2443.2011.01552.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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