Crystal structure of CK2alpha with pyradine derivertive

Summary for 3AT4

Related3AT2 3AT3
DescriptorCasein kinase II subunit alpha, [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid (3 entities in total)
Functional Keywordsck2, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight40854.6
Kinoshita, T. (deposition date: 2010-12-23, release date: 2011-11-09, Last modification date: 2011-11-16)
Primary citation
Kinoshita, T.,Sekiguchi, Y.,Fukada, H.,Nakaniwa, T.,Tada, T.,Nakamura, S.,Kitaura, K.,Ohno, H.,Suzuki, Y.,Hirasawa, A.,Nakanishi, I.,Tsujimoto, G.
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase
Mol.Cell.Biochem., 356:97-105, 2011
PubMed: 21735094 (PDB entries with the same primary citation)
DOI: 10.1007/s11010-011-0960-9
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28329 2.7% 1.6% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28