3AMB

Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680

Summary for 3AMB

• Entry DOI: 10.2210/pdb3amb/pdb
• Related: 3AMA
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (4 entities in total)
• Functional Keywords: pka, protein kinase a, surrogate, vx-680, mk-0457, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P17612
• Total number of polymer chains: 2
• Total formula weight: 43547.47

Authors

Pflug, A.,de Oliveira, T.M.,Bossemeyer, D.,Engh, R.A. (deposition date: 2010-08-18, release date: 2011-08-03, Last modification date: 2023-11-01)

• Primary citation: Pflug, A.,de Oliveira, T.M.,Bossemeyer, D.,Engh, R.A.; Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase; Biochem.J., 440:85-93, 2011; PubMed: 21774789; DOI: 10.1042/BJ20110592

Experimental method

X-RAY DIFFRACTION (2.25 Å)