3AMA

Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621

Summary for 3AMA

• Entry DOI: 10.2210/pdb3ama/pdb
• Related: 3AMB
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, ... (4 entities in total)
• Functional Keywords: pka, protein kinase a, surrogate, jnj-7706621, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P17612
• Total number of polymer chains: 2
• Total formula weight: 43477.24

Authors

Pflug, A.,de Oliveira, T.M.,Bossemeyer, D.,Engh, R.A. (deposition date: 2010-08-18, release date: 2011-08-03, Last modification date: 2023-11-01)

• Primary citation: Pflug, A.,de Oliveira, T.M.,Bossemeyer, D.,Engh, R.A.; Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase; Biochem.J., 440:85-93, 2011; PubMed: 21774789; DOI: 10.1042/BJ20110592

Experimental method

X-RAY DIFFRACTION (1.75 Å)