3AMA
Protein kinase A sixfold mutant model of Aurora B with inhibitor JNJ-7706621
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 351 | 40856.5 | 1 | UniProt (P17612) Pfam (PF00069) In PDB | Homo sapiens (human) | PKA, PKA C-alpha |
| 2 | B | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P61925) In PDB | Homo sapiens | PKI, PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform |
| 3 | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide | non-polymer | 394.4 | 1 | Chemie (SKE) | |||
| 4 | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P17612)
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Lys 48 | engineered mutation |
| Gln 95 | Leu 96 | engineered mutation |
| Leu 120 | Met 121 | engineered mutation |
| Ala 123 | Val 124 | engineered mutation |
| Lys 181 | Gln 182 | engineered mutation |
| Ala 183 | Thr 184 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43082.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 394.4 | |
| All* | Total formula weight | 43477.2 |
