3AGL
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1039
Summary for 3AGL
Entry DOI | 10.2210/pdb3agl/pdb |
Related | 3ag9 3agm 3BWJ |
Related PRD ID | PRD_000642 |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, (10R,20R,23R)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamido propyl)-10-methyl-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide (3 entities in total) |
Functional Keywords | pka, protein kinase a, bisubstrate inhibitor, arc-1039, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P17612 |
Total number of polymer chains | 2 |
Total formula weight | 83557.10 |
Authors | Pflug, A.,Ragozina, J.,Uri, A.,Bossemeyer, D.,Engh, R.A. (deposition date: 2010-04-02, release date: 2010-09-01, Last modification date: 2023-08-30) |
Primary citation | Pflug, A.,Rogozina, J.,Lavogina, D.,Enkvist, E.,Uri, A.,Engh, R.A.,Bossemeyer, D. Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions. J.Mol.Biol., 403:66-77, 2010 Cited by PubMed: 20732331DOI: 10.1016/j.jmb.2010.08.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report