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3AG9

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1012

Summary for 3AG9
Entry DOI10.2210/pdb3ag9/pdb
Related3BWJ 3agl 3agm
Related PRD IDPRD_000641
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, (10R,20R,23R)-10-(4-aminobutyl)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamidopropyl)-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide (3 entities in total)
Functional Keywordspka, protein kinase a, bisubstrate inhibitor, arc-1012, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceBos taurus (bovine)
Cellular locationCytoplasm: P00517
Total number of polymer chains2
Total formula weight82622.32
Authors
Pflug, A.,Lavogina, D.,Uri, A.,Engh, R.A.,Bossemeyer, D. (deposition date: 2010-03-26, release date: 2010-09-01, Last modification date: 2023-08-30)
Primary citationPflug, A.,Rogozina, J.,Lavogina, D.,Enkvist, E.,Uri, A.,Engh, R.A.,Bossemeyer, D.
Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol., 403:66-77, 2010
Cited by
PubMed: 20732331
DOI: 10.1016/j.jmb.2010.08.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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