3AGM
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670
Summary for 3AGM
Entry DOI | 10.2210/pdb3agm/pdb |
Related | 3ag9 3agl 3BWJ |
Related PRD ID | PRD_001021 |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, N~2~-{8-OXO-8-[4-(9H-PURIN-6-YL)PIPERAZIN-1-YL]OCTANOYL}-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGININAMIDE (3 entities in total) |
Functional Keywords | pka, protein kinase a, bisubstrate, bisubstrate inhibitor, arc-670, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P17612 |
Total number of polymer chains | 2 |
Total formula weight | 42110.15 |
Authors | Pflug, A.,Ragozina, J.,Uri, A.,Bossemeyer, D.,Engh, R.A. (deposition date: 2010-04-02, release date: 2010-09-01, Last modification date: 2023-11-15) |
Primary citation | Pflug, A.,Rogozina, J.,Lavogina, D.,Enkvist, E.,Uri, A.,Engh, R.A.,Bossemeyer, D. Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions. J.Mol.Biol., 403:66-77, 2010 Cited by PubMed: 20732331DOI: 10.1016/j.jmb.2010.08.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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