3AG9
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1012
Summary for 3AG9
Entry DOI | 10.2210/pdb3ag9/pdb |
Related | 3agl 3agm 3BWJ |
Related PRD ID | PRD_000641 |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, (10R,20R,23R)-10-(4-aminobutyl)-1-[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-20,23-bis(3-carbamimidamidopropyl)-1,8,11,18,21-pentaoxo-2,9,12,19,22-pentaazatetracosan-24-amide (3 entities in total) |
Functional Keywords | pka, protein kinase a, bisubstrate inhibitor, arc-1012, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Bos taurus (bovine) |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 82622.32 |
Authors | Pflug, A.,Lavogina, D.,Uri, A.,Engh, R.A.,Bossemeyer, D. (deposition date: 2010-03-26, release date: 2010-09-01, Last modification date: 2023-08-30) |
Primary citation | Pflug, A.,Rogozina, J.,Lavogina, D.,Enkvist, E.,Uri, A.,Engh, R.A.,Bossemeyer, D. Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions. J.Mol.Biol., 403:66-77, 2010 Cited by PubMed: 20732331DOI: 10.1016/j.jmb.2010.08.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report