3A78

Crystal structure of the human VDR ligand binding domain bound to the natural metabolite 1alpha,25-dihydroxy-3-epi-vitamin D3

Summary for 3A78

• Entry DOI: 10.2210/pdb3a78/pdb
• Related: 1DB1
• Descriptor: Vitamin D3 receptor, (1S,3S,5Z,7E,14beta,17alpha)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transcription, gene regulation, disease mutation, dna-binding, metal-binding, nucleus, phosphoprotein, receptor, transcription regulation, zinc-finger
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P11473
• Total number of polymer chains: 1
• Total formula weight: 30414.10

Authors

Sato, Y.,Sigueiro, R.,Antony, P.,Rochel, N.,Moras, D. (deposition date: 2009-09-18, release date: 2010-10-13, Last modification date: 2023-11-01)

• Primary citation: Molnar, F.,Sigueiro, R.,Sato, Y.,Antony, P.,Mourino, A.,Rochel, N.,Moras, D.; Structural basis of the activation of the human Vitamin D receptor by the natural metabolite 1alpha,25-dihydroxy-3-epi-vitamin D3; To be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)