3A51
Structure of cytochrome P450 Vdh mutant (Vdh-K1) obtained by directed evolution with bound 25-hydroxyvitamin D3
Summary for 3A51
Entry DOI | 10.2210/pdb3a51/pdb |
Related | 3A4G 3A4H 3A4Z 3A50 |
Descriptor | Vitamin D hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL, ... (7 entities in total) |
Functional Keywords | cytochrome p450, vitamin d3 hydroxylase, hemoprotein, monooxygenase, directed evolution, oxidoreductase |
Biological source | Pseudonocardia autotrophica |
Cellular location | Cytoplasm : C4B644 |
Total number of polymer chains | 5 |
Total formula weight | 233863.02 |
Authors | Yasutake, Y.,Fujii, Y.,Cheon, W.K.,Arisawa, A.,Tamura, T. (deposition date: 2009-07-24, release date: 2010-07-28, Last modification date: 2023-11-01) |
Primary citation | Yasutake, Y.,Fujii, Y.,Nishioka, T.,Cheon, W.K.,Arisawa, A.,Tamura, T. Structural evidence for enhancement of sequential vitamin D3 hydroxylation activities by directed evolution of cytochrome P450 vitamin D3 hydroxylase J.Biol.Chem., 285:31193-31201, 2010 Cited by PubMed: 20667833DOI: 10.1074/jbc.M110.147009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)