3A4U

Crystal structure of MCFD2 in complex with carbohydrate recognition domain of ERGIC-53

Summary for 3A4U

• Entry DOI: 10.2210/pdb3a4u/pdb
• Descriptor: Protein ERGIC-53, Multiple coagulation factor deficiency protein 2, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: lectin, ergic, er, golgi, transport, disulfide bond, endoplasmic reticulum, er-golgi transport, golgi apparatus, membrane, protein transport, transmembrane, disease mutation
• Biological source: Homo sapiens (human); More
• Cellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein: P49257; Endoplasmic reticulum-Golgi intermediate compartment : Q8NI22
• Total number of polymer chains: 2
• Total formula weight: 44884.60

Authors

Nishio, M.,Kamiya, Y.,Mizushima, T.,Wakatsuki, S.,Sasakawa, H.,Yamamoto, K.,Uchiyama, S.,Noda, M.,McKay, A.R.,Fukui, K.,Hauri, H.P.,Kato, K. (deposition date: 2009-07-17, release date: 2010-01-05, Last modification date: 2023-11-01)

• Primary citation: Nishio, M.,Kamiya, Y.,Mizushima, T.,Wakatsuki, S.,Sasakawa, H.,Yamamoto, K.,Uchiyama, S.,Noda, M.,McKay, A.R.,Fukui, K.,Hauri, H.P.,Kato, K.; Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency.; Proc.Natl.Acad.Sci.USA, 107:4034-4039, 2010; PubMed: 20142513; DOI: 10.1073/pnas.0908526107

Experimental method

X-RAY DIFFRACTION (1.84 Å)