3A4U

Crystal structure of MCFD2 in complex with carbohydrate recognition domain of ERGIC-53

3A4U の概要

• エントリーDOI: 10.2210/pdb3a4u/pdb
• 分子名称: Protein ERGIC-53, Multiple coagulation factor deficiency protein 2, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: lectin, ergic, er, golgi, transport, disulfide bond, endoplasmic reticulum, er-golgi transport, golgi apparatus, membrane, protein transport, transmembrane, disease mutation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein: P49257; Endoplasmic reticulum-Golgi intermediate compartment : Q8NI22
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44884.60

構造登録者

Nishio, M.,Kamiya, Y.,Mizushima, T.,Wakatsuki, S.,Sasakawa, H.,Yamamoto, K.,Uchiyama, S.,Noda, M.,McKay, A.R.,Fukui, K.,Hauri, H.P.,Kato, K. (登録日: 2009-07-17, 公開日: 2010-01-05, 最終更新日: 2023-11-01)

• 主引用文献: Nishio, M.,Kamiya, Y.,Mizushima, T.,Wakatsuki, S.,Sasakawa, H.,Yamamoto, K.,Uchiyama, S.,Noda, M.,McKay, A.R.,Fukui, K.,Hauri, H.P.,Kato, K.; Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency.; Proc.Natl.Acad.Sci.USA, 107:4034-4039, 2010; PubMed: 20142513; DOI: 10.1073/pnas.0908526107

実験手法

X-RAY DIFFRACTION (1.84 Å)