3A4P

human c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor

3A4P の概要

• エントリーDOI: 10.2210/pdb3a4p/pdb
• 関連するPDBエントリー: 1r1w 2wgj
• 分子名称: Hepatocyte growth factor receptor, CHLORIDE ION, ISOPROPYL ALCOHOL, ... (5 entities in total)
• 機能のキーワード: c-met, tyrosine-protein kinase, hepatocyte growth factor receptor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36562.61

構造登録者

Fukami, T.A.,Kadono, S.,Yamamuro, M.,Matsuura, T. (登録日: 2009-07-13, 公開日: 2010-02-16, 最終更新日: 2023-11-01)

主引用文献

Nishii, H.,Chiba, T.,Morikami, K.,Fukami, T.A.,Sakamoto, H.,Ko, K.,Koyano, H.
Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors
Bioorg.Med.Chem.Lett., 20:1405-1409, 2010

PubMed Abstract: A novel quinoline derivative that selectively inhibits c-Met kinase was identified. The molecular design is based on a result of the analysis of a PF-2341066 (1)/c-Met cocrystal structure (PDB code: 2wgj). The kinase selectivity of the derivatives is discussed from the view point of the sequence homology of the kinases, the key interactions found in X-ray cocrystal structures, and the structure-activity relationship (SAR) obtained in this work.

PubMed: 20093027
DOI: 10.1016/j.bmcl.2009.12.109

実験手法

X-RAY DIFFRACTION (2.54 Å)