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3A3Z

Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)

Summary for 3A3Z
Entry DOI10.2210/pdb3a3z/pdb
Related1DB1 2HB8 3A40 3CS4
DescriptorVitamin D3 receptor, (1S,2S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-2-methyl-9,10-secoandrosta-5,7,10-triene-1,3-diol, SULFATE ION, ... (4 entities in total)
Functional Keywordstranscription, structural genomics, spine2, structural proteomics in europe 2, gene regulation, spine-2
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P11473
Total number of polymer chains1
Total formula weight30456.14
Authors
Sato, Y.,Antony, P.,Huet, T.,Sigueiro, R.,Rochel, N.,Moras, D.,Structural Proteomics in Europe 2 (SPINE-2) (deposition date: 2009-06-25, release date: 2010-02-02, Last modification date: 2023-11-01)
Primary citationAntony, P.,Sigueiro, R.,Huet, T.,Sato, Y.,Ramalanjaona, N.,Rodrigues, L.C.,Mourino, A.,Moras, D.,Rochel, N.
Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3
J.Med.Chem., 53:1159-1171, 2010
Cited by
PubMed: 20070104
DOI: 10.1021/jm9014636
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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