3WGW
Structure of PCNA bound to a small molecule inhibitor
Summary for 3WGW
Entry DOI | 10.2210/pdb3wgw/pdb |
Descriptor | Proliferating cell nuclear antigen, 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | dna binding, dna binding protein-inhibitor complex, dna binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 59316.91 |
Authors | Hashimoto, H. (deposition date: 2013-08-12, release date: 2014-02-05, Last modification date: 2023-11-08) |
Primary citation | Inoue, A.,Kikuchi, S.,Hishiki, A.,Shao, Y.,Heath, R.,Evison, B.J.,Actis, M.,Canman, C.E.,Hashimoto, H.,Fujii, N. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289:7109-7120, 2014 Cited by PubMed: 24474685DOI: 10.1074/jbc.M113.520429 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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