3W12

Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7

Summary for 3W12
Related2DTG 2WRW 3LOH 3W11 3W13 3W14
DescriptorInsulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ... (9 entities in total)
Functional Keywordscell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, insulin, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system
Biological sourceHomo sapiens (human)
More
Total number of polymer chains6
Total formula weight69922.35
Authors
Lawrence, M.C.,Smith, B.J.,Brzozowsk, A.M. (deposition date: 2012-11-06, release date: 2013-01-09, Last modification date: 2020-07-29)
Primary citationBrzozowski, A.M.,Chan, S.J.,Dodson, G.G.,Jiracek, J.,Kletvikova, E.,Kong, G.K.-W.,Lawrence, M.C.,Margetts, M.B.,Menting, J.G.,Smith, B.J.,Steiner, D.F.,Ward, C.W.,Watson, C.J.,Weiss, M.A.,Whittaker, J.,Whittaker, L.J.,Zakova, L.
How insulin engages its primary binding site on the insulin receptor
Nature, 493:241-245, 2013
PubMed: 23302862
DOI: 110.1038/nature11781
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4.301 Å)
Structure validation
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PDB entries from 2021-06-16