3VHV
Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist
Summary for 3VHV
Entry DOI | 10.2210/pdb3vhv/pdb |
Related | 3VHU |
Descriptor | Mineralocorticoid receptor, 6-[(7S)-7-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-2H-1,4-benzoxazin-3(4H)-one, 6-[(1E)-2-phenyl-N-(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]-2H-1,4-benzoxazin-3(4H)-one, ... (6 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, activating mutation, hypertension, non-steroidal antagonist, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 1 |
Total formula weight | 31051.99 |
Authors | Sogabe, S.,Habuka, N. (deposition date: 2011-09-07, release date: 2011-12-28, Last modification date: 2023-11-08) |
Primary citation | Hasui, T.,Matsunaga, N.,Ora, T.,Ohyabu, N.,Nishigaki, N.,Imura, Y.,Igata, Y.,Matsui, H.,Motoyaji, T.,Tanaka, T.,Habuka, N.,Sogabe, S.,Ono, M.,Siedem, C.S.,Tang, T.P.,Gauthier, C.,De Meese, L.A.,Boyd, S.A.,Fukumoto, S. Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists J.Med.Chem., 54:8616-8631, 2011 Cited by PubMed: 22074142DOI: 10.1021/jm2011645 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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