3VHV
Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE LD1 A 1 |
| Chain | Residue |
| A | HOH9 |
| A | MET845 |
| A | MET852 |
| A | PHE941 |
| A | CYS942 |
| A | THR945 |
| A | VAL954 |
| A | PHE956 |
| A | LEU769 |
| A | ASN770 |
| A | LEU772 |
| A | GLN776 |
| A | MET807 |
| A | LEU810 |
| A | SER811 |
| A | PHE829 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE LD2 A 2 |
| Chain | Residue |
| A | HOH153 |
| A | LEU766 |
| A | ALA844 |
| A | MET845 |
| A | TYR846 |
| A | GLU847 |
| A | LEU848 |
| A | ILE900 |
| A | LYS901 |
| A | ARG904 |
| A | TRP918 |
| A | PHE941 |
| A | TYR944 |
| A | THR945 |
| A | LEU952 |
| A | EDO985 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 985 |
| Chain | Residue |
| A | LD22 |
| A | HOH35 |
| A | HOH41 |
| A | ARG896 |
| A | THR897 |
| A | ILE900 |
| A | GLU948 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 986 |
| Chain | Residue |
| A | PRO788 |
| A | TYR899 |
| A | GLU902 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 3 |
| Chain | Residue |
| A | HOH18 |
| A | HOH52 |
| A | HOH260 |
| A | TYR980 |
| A | ARG983 |
| A | LYS984 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Region: {"description":"Important for coactivator binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15908963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
