3VHV
Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mineralocorticoid receptor | polymer | 260 | 30160.0 | 1 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR, Nuclear receptor subfamily 3 group C member 2 |
| 2 | B (A) | 6-[(7S)-7-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 363.4 | 1 | Chemie (LD1) | |||
| 3 | C (A) | 6-[(1E)-2-phenyl-N-(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 365.4 | 1 | Chemie (LD2) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 6 | G (A) | water | water | 18.0 | 270 | Chemie (HOH) |
Sequence modifications
A: 727 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Gly 725 | - | expression tag |
| Ser 726 | - | expression tag |
| Ser 808 | Cys 808 | engineered mutation |
| Leu 810 | Ser 810 | engineered mutation |
| Val 976 | Ala 976 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30160.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 892.0 | |
| All* | Total formula weight | 31052.0 |
