3VHK
Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder
Summary for 3VHK
Entry DOI | 10.2210/pdb3vhk/pdb |
Descriptor | Vascular endothelial growth factor receptor 2, {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | vegfr2, kinase domain, complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 42162.22 |
Authors | Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Hixon, M.S.,Kimura, H.,Miki, H. (deposition date: 2011-08-25, release date: 2012-09-05, Last modification date: 2024-03-20) |
Primary citation | Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Lawson, J.D.,Hixon, M.S.,Kimura, H.,Miki, H. A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3:342-346, 2012 Cited by PubMed: 24900475DOI: 10.1021/ml3000403 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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