3UTU
High affinity inhibitor of human thrombin
Summary for 3UTU
| Entry DOI | 10.2210/pdb3utu/pdb |
| Related | 2zfo 2ziq 3dt0 3dux 3eqo 3f68 |
| Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total) |
| Functional Keywords | serine protease, blood clotting, fibrinopeptide a, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
| Total number of polymer chains | 3 |
| Total formula weight | 36023.36 |
| Authors | Baum, B.,Steinmetzer, T.,Heine, A.,Klebe, G. (deposition date: 2011-11-26, release date: 2012-08-29, Last modification date: 2023-12-06) |
| Primary citation | Steinmetzer, T.,Baum, B.,Biela, A.,Klebe, G.,Nowak, G.,Bucha, E. Beyond heparinization: design of highly potent thrombin inhibitors suitable for surface coupling Chemmedchem, 7:1965-1973, 2012 Cited by PubMed: 22907907DOI: 10.1002/cmdc.201200292 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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