3UP3
Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-cholestenoic acid
Summary for 3UP3
Entry DOI | 10.2210/pdb3up3/pdb |
Related | 3UP0 |
Descriptor | aceDAF-12, Nuclear receptor coactivator 2, (8alpha,10alpha,25S)-3-hydroxycholesta-3,5-dien-26-oic acid, ... (5 entities in total) |
Functional Keywords | ligand binding domain, nematode, steroid binding protein-transcription complex, steroid binding protein/transcription |
Biological source | Ancylostoma ceylanicum More |
Cellular location | Nucleus: Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 30238.62 |
Authors | Zhi, X.,Zhou, X.E.,Melcher, K.,Motola, D.L.,Gelmedin, V.,Hawdon, J.,Kliewer, S.A.,Mangelsdorf, D.J.,Xu, H.E. (deposition date: 2011-11-17, release date: 2011-12-14, Last modification date: 2024-02-28) |
Primary citation | Zhi, X.,Zhou, X.E.,Melcher, K.,Motola, D.L.,Gelmedin, V.,Hawdon, J.,Kliewer, S.A.,Mangelsdorf, D.J.,Xu, H.E. Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes. J.Biol.Chem., 287:4894-4903, 2012 Cited by PubMed: 22170062DOI: 10.1074/jbc.M111.315242 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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