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3UMH

X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium

Summary for 3UMH
Entry DOI10.2210/pdb3umh/pdb
Related3UMI 3UMK
DescriptorAmyloid beta A4 protein, ACETATE ION, CADMIUM ION, ... (4 entities in total)
Functional Keywordsmetal binding site, metal binding, cell surface, secretory pathway, metal binding protein
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P05067
Total number of polymer chains1
Total formula weight26192.19
Authors
Dahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Than, M.E. (deposition date: 2011-11-13, release date: 2012-01-25, Last modification date: 2024-02-28)
Primary citationDahms, S.O.,Konnig, I.,Roeser, D.,Guhrs, K.H.,Mayer, M.C.,Kaden, D.,Multhaup, G.,Than, M.E.
Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain.
J.Mol.Biol., 416:438-452, 2012
Cited by
PubMed: 22245578
DOI: 10.1016/j.jmb.2011.12.057
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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