3UIC
Crystal Structure of FabI, an Enoyl Reductase from F. tularensis, in complex with a Novel and Potent Inhibitor
Summary for 3UIC
Entry DOI | 10.2210/pdb3uic/pdb |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole, ... (4 entities in total) |
Functional Keywords | rossmann fold, enoyl reductase, nadh binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Francisella tularensis subsp. tularensis |
Total number of polymer chains | 16 |
Total formula weight | 495603.01 |
Authors | Mehboob, S.,Santarsiero, B.D.,Truong, K.,Johnson, M.E. (deposition date: 2011-11-04, release date: 2012-06-06, Last modification date: 2023-09-13) |
Primary citation | Mehboob, S.,Hevener, K.E.,Truong, K.,Boci, T.,Santarsiero, B.D.,Johnson, M.E. Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors. J.Med.Chem., 55:5933-5941, 2012 Cited by PubMed: 22642319DOI: 10.1021/jm300489v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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