3UHM

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase in complex with inhibitor

Summary for 3UHM

• Entry DOI: 10.2210/pdb3uhm/pdb
• Related: 3U1Y
• Descriptor: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide, ... (6 entities in total)
• Functional Keywords: amidohydrolases, anti-bacterial agents, bacteria, catalytic domain, drug design, enzyme inhibitors, gram negative, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 33697.58

Authors

Montgomery, J.,Liu, S. (deposition date: 2011-11-03, release date: 2012-02-01, Last modification date: 2023-09-13)

Primary citation

Montgomery, J.I.,Brown, M.F.,Reilly, U.,Price, L.M.,Abramite, J.A.,Arcari, J.,Barham, R.,Che, Y.,Chen, J.M.,Chung, S.W.,Collantes, E.M.,Desbonnet, C.,Doroski, M.,Doty, J.,Engtrakul, J.J.,Harris, T.M.,Huband, M.,Knafels, J.D.,Leach, K.L.,Liu, S.,Marfat, A.,McAllister, L.,McElroy, E.,Menard, C.A.,Mitton-Fry, M.,Mullins, L.,Noe, M.C.,O'Donnell, J.,Oliver, R.,Penzien, J.,Plummer, M.,Shanmugasundaram, V.,Thoma, C.,Tomaras, A.P.,Uccello, D.P.,Vaz, A.,Wishka, D.G.
Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J.Med.Chem., 55:1662-1670, 2012

PubMed Abstract: The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously described biphenyl methylsulfone hydroxamate series, and they maintain superior Gram-negative antibacterial activity to comparator agents.

PubMed: 22257165
DOI: 10.1021/jm2014875

Experimental method

X-RAY DIFFRACTION (1.26 Å)