3UAN
Crystal structure of 3-O-sulfotransferase (3-OST-1) with bound PAP and heptasaccharide substrate
Summary for 3UAN
Entry DOI | 10.2210/pdb3uan/pdb |
Related | 1T8T 1T8U 1ZRH |
Descriptor | Heparan sulfate glucosamine 3-O-sulfotransferase 1, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | sulfotransferase, heparan sulfate, alpha/beta motif, co-factor paps/pap, heparan sulfate oligosaccharides, golgi-localized, transferase |
Biological source | Mus musculus (mouse) |
Cellular location | Golgi apparatus lumen (Probable): O35310 |
Total number of polymer chains | 2 |
Total formula weight | 66784.72 |
Authors | Moon, A.F.,Xu, Y.,Woody, S.M.,Krahn, J.M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C. (deposition date: 2011-10-21, release date: 2012-04-04, Last modification date: 2023-09-13) |
Primary citation | Moon, A.F.,Xu, Y.,Woody, S.M.,Krahn, J.M.,Linhardt, R.J.,Liu, J.,Pedersen, L.C. Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin. Proc.Natl.Acad.Sci.USA, 109:5265-5270, 2012 Cited by PubMed: 22431632DOI: 10.1073/pnas.1117923109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.844 Å) |
Structure validation
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