3U2O
Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor
Summary for 3U2O
| Entry DOI | 10.2210/pdb3u2o/pdb |
| Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total) |
| Functional Keywords | dhodh, dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Mitochondrion inner membrane; Single-pass membrane protein: Q02127 |
| Total number of polymer chains | 1 |
| Total formula weight | 44279.26 |
| Authors | Lozoya, E.,Segarra, V.,Erra, M.,Wenzkowski, C.,Jestel, A.,Krapp, S.,Blaesse, M. (deposition date: 2011-10-04, release date: 2011-11-16, Last modification date: 2023-09-13) |
| Primary citation | Erra, M.,Moreno, I.,Sanahuja, J.,Andres, M.,Reinoso, R.F.,Lozoya, E.,Pizcueta, P.,Godessart, N.,Castro-Palomino, J.C. Biaryl analogues of teriflunomide as potent DHODH inhibitors. Bioorg.Med.Chem.Lett., 21:7268-7272, 2011 Cited by PubMed: 22078215DOI: 10.1016/j.bmcl.2011.10.052 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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