3U15
Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443
Summary for 3U15
Entry DOI | 10.2210/pdb3u15/pdb |
Related | 3FEA 3VBG |
Descriptor | Protein Mdm4, (5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione, SULFATE ION, ... (4 entities in total) |
Functional Keywords | cell cycle, ubiquitin ligase, mdm2, mdmx, p53, protein binding |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O15151 |
Total number of polymer chains | 4 |
Total formula weight | 46547.24 |
Authors | Lukacs, C.M.,Janson, C.A.,Graves, B.J. (deposition date: 2011-09-29, release date: 2012-06-27, Last modification date: 2023-09-13) |
Primary citation | Graves, B.,Thompson, T.,Xia, M.,Janson, C.,Lukacs, C.,Deo, D.,Di Lello, P.,Fry, D.,Garvie, C.,Huang, K.S.,Gao, L.,Tovar, C.,Lovey, A.,Wanner, J.,Vassilev, L.T. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc.Natl.Acad.Sci.USA, 109:11788-11793, 2012 Cited by PubMed: 22745160DOI: 10.1073/pnas.1203789109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report