3U15
Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| D | 0005634 | cellular_component | nucleus |
| D | 0043066 | biological_process | negative regulation of apoptotic process |
| D | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 03M A 1 |
| Chain | Residue |
| A | GLY57 |
| B | MET53 |
| B | GLY57 |
| B | ILE60 |
| B | PHE90 |
| B | VAL92 |
| B | LEU98 |
| A | ILE60 |
| A | MET61 |
| A | TYR66 |
| A | GLN71 |
| A | VAL92 |
| A | HOH118 |
| A | HOH121 |
| B | 03M1 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 112 |
| Chain | Residue |
| A | GLN71 |
| A | HIS72 |
| A | LYS93 |
| B | GLU70 |
| B | GLN71 |
| B | HIS72 |
| B | LYS93 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 03M B 1 |
| Chain | Residue |
| A | 03M1 |
| A | MET53 |
| A | LEU56 |
| A | GLY57 |
| A | PHE90 |
| A | VAL92 |
| A | LEU98 |
| B | GLY57 |
| B | ILE60 |
| B | MET61 |
| B | TYR66 |
| B | GLN71 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 03M C 1 |
| Chain | Residue |
| C | ILE60 |
| C | MET61 |
| C | TYR66 |
| C | GLN71 |
| C | VAL92 |
| C | HOH118 |
| C | HOH136 |
| D | 03M1 |
| D | MET53 |
| D | LEU56 |
| D | GLY57 |
| D | ILE60 |
| D | VAL92 |
| D | LEU98 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 03M D 1 |
| Chain | Residue |
| C | 03M1 |
| C | MET53 |
| C | LEU56 |
| C | GLY57 |
| C | ILE60 |
| C | GLN71 |
| C | PHE90 |
| C | VAL92 |
| C | LEU98 |
| D | GLY57 |
| D | ILE60 |
| D | MET61 |
| D | TYR66 |
| D | GLN68 |
| D | GLN71 |
| D | HOH119 |
| D | HOH139 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2 |
| Chain | Residue |
| C | GLN71 |
| C | HIS72 |
| D | GLU70 |
| D | GLN71 |
| D | HIS72 |
