3U15

Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Protein Mdm4	polymer	100	11187.0	4	UniProt (O15151)	Homo sapiens (human)	Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4
2	E, G, H, I (A, B, C, D)	(5Z)-5-[(6-chloro-7-methyl-1H-indol-3-yl)methylidene]-3-(3,4-difluorobenzyl)imidazolidine-2,4-dione	non-polymer		401.8	4	Chemie (03M)
3	F, J (A, D)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	K, L, M, N (A, B, C, D)	water	water		18.0	149	Chemie (HOH)

Sequence modifications

A, B, C, D: 14 - 111 (UniProt: O15151)

PDB	External Database	Details
Gly 12	-	expression tag
Pro 13	-	expression tag
Ser 17	Cys 17	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	44747.9
Non-Polymers*	Number of molecules	6
	Total formula weight	1799.3
All*	Total formula weight	46547.2

*Water molecules are not included.