3TWJ
Rho-associated protein kinase 1 (ROCK 1) IN COMPLEX WITH RKI1447
Summary for 3TWJ
Entry DOI | 10.2210/pdb3twj/pdb |
Descriptor | Rho-associated protein kinase 1, 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase, dimer, dimerization, myosin, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13464 |
Total number of polymer chains | 4 |
Total formula weight | 190781.59 |
Authors | Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-09-21, release date: 2012-08-22, Last modification date: 2023-09-13) |
Primary citation | Patel, R.A.,Forinash, K.D.,Pireddu, R.,Sun, Y.,Sun, N.,Martin, M.P.,Schonbrunn, E.,Lawrence, N.J.,Sebti, S.M. RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer. Cancer Res., 72:5025-5034, 2012 Cited by PubMed: 22846914DOI: 10.1158/0008-5472.CAN-12-0954 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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