3TPJ

APO structure of BACE1

Summary for 3TPJ

Entry DOI	10.2210/pdb3tpj/pdb
Related	3TPL 3TPP 3TPR
Descriptor	Beta-secretase 1, SULFATE ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hydrolase, protease, memapsin 2, bace1
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	49267.10
Authors	Xu, Y.C.,Li, M.J.,Greenblatt, H.,Chen, T.T.,Silman, I.,Sussman, J.L. (deposition date: 2011-09-08, release date: 2011-11-23, Last modification date: 2023-11-01)
Primary citation	Xu, Y.C.,Li, M.J.,Greenblatt, H.,Chen, W.Y.,Paz, A.,Dym, O.,Peleg, Y.,Chen, T.T.,Shen, X.,He, J.H.,Jiang, H.L.,Silman, I.,Sussman, J.L. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Acta Crystallogr.,Sect.D, 68:13-25, 2012 Cited by PubMed: 22194329 DOI: 10.1107/S0907444911047251 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation