3TPL
APO Structure of BACE1
Summary for 3TPL
Entry DOI | 10.2210/pdb3tpl/pdb |
Related | 3TPJ 3TPP 3TPR |
Descriptor | Beta-secretase 1, SULFATE ION, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | hydrolase, memapsin 2, protease, beta-secretase 1 |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 3 |
Total formula weight | 144992.41 |
Authors | Xu, Y.C.,Li, M.J.,Greenblatt, H.,Chen, T.T.,Silman, I.,Sussman, J.L. (deposition date: 2011-09-08, release date: 2011-11-23, Last modification date: 2023-11-01) |
Primary citation | Xu, Y.C.,Li, M.J.,Greenblatt, H.,Chen, W.Y.,Paz, A.,Dym, O.,Peleg, Y.,Chen, T.T.,Shen, X.,He, J.H.,Jiang, H.L.,Silman, I.,Sussman, J.L. Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Acta Crystallogr.,Sect.D, 68:13-25, 2012 Cited by PubMed: 22194329DOI: 10.1107/S0907444911047251 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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