3TKG

crystal structure of HIV model protease precursor/saquinavir complex

Summary for 3TKG

Entry DOI	10.2210/pdb3tkg/pdb
Related PRD ID	PRD_000454
Descriptor	Protease, CHLORIDE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	4
Total formula weight	46520.40
Authors	Agniswamy, J.,Sayer, J.,Weber, I.,Louis, J. (deposition date: 2011-08-26, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citation	Agniswamy, J.,Sayer, J.M.,Weber, I.T.,Louis, J.M. Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease. Biochemistry, 51:1041-1050, 2012 Cited by PubMed: 22242794 DOI: 10.1021/bi201809s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation