3TKD

Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution

Summary for 3TKD

• Entry DOI: 10.2210/pdb3tkd/pdb
• Related: 1LB9 1LBB 1LBC 3H6T 3IL1
• Descriptor: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, CYCLOTHIAZIDE, ... (6 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, glua2 s1s2j-l483y-n754s, cyclothiazide, allosteric modulation, membrane protein
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 2
• Total formula weight: 60423.97

Authors

Krintel, C.,Frydenvang, K.,Gajhede, M.,Kastrup, J.S. (deposition date: 2011-08-26, release date: 2011-09-21, Last modification date: 2023-09-13)

• Primary citation: Krintel, C.,Frydenvang, K.,Olsen, L.,Kristensen, M.T.,de Barrios, O.,Naur, P.,Francotte, P.,Pirotte, B.,Gajhede, M.,Kastrup, J.S.; Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.; Biochem.J., 441:173-178, 2012; PubMed: 21895609; DOI: 10.1042/BJ20111221

Experimental method

X-RAY DIFFRACTION (1.45 Å)