3TJS

Crystal Structure of the complex between human cytochrome P450 3A4 and desthiazolylmethyloxycarbonyl ritonavir

Summary for 3TJS

Entry DOI	10.2210/pdb3tjs/pdb
Related	3NXU
Related PRD ID	PRD_001003
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide, ... (4 entities in total)
Functional Keywords	monooxygenase, cytochrome p450, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P08684
Total number of polymer chains	1
Total formula weight	56954.10
Authors	Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2011-08-24, release date: 2012-03-07, Last modification date: 2023-09-13)
Primary citation	Sevrioukova, I.F.,Poulos, T.L. Interaction of human cytochrome P4503A4 with ritonavir analogs. Arch.Biochem.Biophys., 520:108-116, 2012 Cited by PubMed: 22410611 DOI: 10.1016/j.abb.2012.02.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation