3TAM

Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06

Summary for 3TAM

• Entry DOI: 10.2210/pdb3tam/pdb
• Related: 3T19 3T1A
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, 3-chloro-5-{[4-methyl-2-oxo-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1,2-dihydropyridin-3-yl]oxy}benzonitrile, ... (4 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltranferase, k103n, hiv-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: HIV-1 M:B_HXB2R (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116988.39

Authors

Yan, Y. (deposition date: 2011-08-04, release date: 2011-10-26, Last modification date: 2023-09-13)

• Primary citation: Gomez, R.,Jolly, S.,Williams, T.,Tucker, T.,Tynebor, R.,Vacca, J.,McGaughey, G.,Lai, M.T.,Felock, P.,Munshi, V.,DeStefano, D.,Touch, S.,Miller, M.,Yan, Y.,Sanchez, R.,Liang, Y.,Paton, B.,Wan, B.L.,Anthony, N.; Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.; Bioorg.Med.Chem.Lett., 21:7344-7350, 2011; PubMed: 22071300; DOI: 10.1016/j.bmcl.2011.10.027

Experimental method

X-RAY DIFFRACTION (2.51 Å)