3T5O
Crystal Structure of human Complement Component C6
Summary for 3T5O
Entry DOI | 10.2210/pdb3t5o/pdb |
Descriptor | Complement component C6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, ... (6 entities in total) |
Functional Keywords | macpf, mac, membrane attack complex, complement, innate immune system, blood, membrane, c7, c8, c9, cytolysin, immune system |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P13671 |
Total number of polymer chains | 1 |
Total formula weight | 104289.20 |
Authors | Aleshin, A.E.,Stec, B.,Bankston, L.A.,DiScipio, R.G.,Liddington, R.C. (deposition date: 2011-07-27, release date: 2012-02-01, Last modification date: 2020-07-29) |
Primary citation | Aleshin, A.E.,Schraufstatter, I.U.,Stec, B.,Bankston, L.A.,Liddington, R.C.,Discipio, R.G. Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC). J.Biol.Chem., 287:10210-10222, 2012 Cited by PubMed: 22267737DOI: 10.1074/jbc.M111.327809 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.869 Å) |
Structure validation
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