3T5O
Crystal Structure of human Complement Component C6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0002376 | biological_process | immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005579 | cellular_component | membrane attack complex |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006955 | biological_process | immune response |
| A | 0006956 | biological_process | complement activation |
| A | 0006958 | biological_process | complement activation, classical pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0044218 | cellular_component | other organism cell membrane |
| A | 0045087 | biological_process | innate immune response |
| A | 0050778 | biological_process | positive regulation of immune response |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0160257 | biological_process | complement activation, GZMK pathway |
| A | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC |
| Chain | Residue | Details |
| A | CYS520-CYS531 |
| site_id | PS00279 |
| Number of Residues | 12 |
| Details | MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY |
| Chain | Residue | Details |
| A | TYR333-TYR344 |
| site_id | PS01209 |
| Number of Residues | 23 |
| Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C |
| Chain | Residue | Details |
| A | CYS130-CYS152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839 |
| Chain | Residue | Details |
| A | TRP8 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | CARBOHYD: C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 |
| Chain | Residue | Details |
| A | TRP11 | |
| A | TRP69 | |
| A | TRP547 | |
| A | TRP550 | |
| A | TRP553 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 |
| Chain | Residue | Details |
| A | THR17 | |
| A | THR371 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22267737 |
| Chain | Residue | Details |
| A | ASN303 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN834 |
