3SR4
Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor
Summary for 3SR4
Entry DOI | 10.2210/pdb3sr4/pdb |
Related | 1NW3 3QOW 3QOX |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | hdot1, histone lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Probable): Q8TEK3 |
Total number of polymer chains | 1 |
Total formula weight | 41396.86 |
Authors | Diao, J.,Chen, P.,Yao, Y.,Prasad, B.V.V.,Song, Y. (deposition date: 2011-07-06, release date: 2011-10-05, Last modification date: 2023-09-13) |
Primary citation | Yao, Y.,Chen, P.,Diao, J.,Cheng, G.,Deng, L.,Anglin, J.L.,Prasad, B.V.,Song, Y. Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies. J.Am.Chem.Soc., 133:16746-16749, 2011 Cited by PubMed: 21936531DOI: 10.1021/ja206312b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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