3SP7
Crystal Structure of Bcl-xL bound to BM903
Summary for 3SP7
Entry DOI | 10.2210/pdb3sp7/pdb |
Related | 3SPF |
Descriptor | Bcl-2-like protein 1, 5-(4-chlorophenyl)-4-{3-[4-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]amino}phenyl)piperazin-1-yl]phenyl}-1,2-dimethyl-1H-pyrrole-3-carboxylic acid, ZINC ION, ... (5 entities in total) |
Functional Keywords | bcl-2-like protein, apoptosis regulator-inhibitor complex, apoptosis regulator/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 1 |
Total formula weight | 21023.88 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2011-07-01, release date: 2012-07-04, Last modification date: 2024-02-28) |
Primary citation | Zhou, H.,Chen, J.,Meagher, J.L.,Aguilar, A.,Bai, L.,Liu, L.,Yang, C.Y.,Xin, C.,Stuckey, J.A.,Wang, S. Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors To be Published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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